Benzalkonium Chloride Solution Ph.Eur 1LT Go Back

CASR

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Molecular Formula

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Molecular Weight

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Specifications  
Appearance: Clear, colourless or slightly yellowish liquid.
Solubility: Miscible with water and with ethanol (96%). It froths copiously when shaken.
Identification A (By UV spectrophotometry): Absorbance maxima should be at 257 nm, 263 nm and 269 nm. Shoulder about 250 nm
Identification B (By Liquid Chromatography): The principal peaks in the chromatogram obtained with the test solution are similar in retention time to the principal peaks in the chromatogram obtained with the reference solution.
Identification C (By Chemical test): The crystals should melt at 127°C to 133°C
Identification D (By Chemical test): The methylene chloride layer should becomes blue.
Identification E (By Chemical test): The precipitate should dissolves easily with the possible exception of a few large particles which dissolve slowly.
Appearance of Solution: Solution should be clear and not more intensely coloured than reference solution Y6.
Acidity or Alkalinity: Not more than 0.1mL of 0.1M hydrochloric acid or 0.1M sodium hydroxide should require to change the colour of the indicator.
Average relative molecular mass and ratio of Alkyl components (C12 homologue): Min. 40.0%
Average relative molecular mass and ratio of Alkyl components (C14 homologue): Min. 20.0%
Average relative molecular mass and ratio of Alkyl components (Sum of C12 and C14 homologue): Min. 70.0%
Impurities A (Benzyl alcohol): Not more than 0.5%
Impurities B (Benzaldehyde): Not more than 0.15%
Impurities C (chloromethyl)benzene: Not more than 0.05%
Amine & amine salts: Not greater than 5.0 mL of 0.1M tetrabutylammonium hydroxide solution required between two points of inflexion.
Sulphated ash: 0.1% max.
Assay: 475g/L to 525 g/L
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