Methylene chloride CDMF 2.5LT Go Back


: 75-09-2

Molecular Formula

: ClCH2Cl

Molecular Weight

: 84.93
Appearance: Clear,colourless, volatile liquid having an odor resembling that of chloroform. (USP/Ph.Eur)
Solubility: Sparingly soluble in water, miscible with ethanol (96%) alcohol, with ether, and with fixed and volatile oils. (USP/Ph.Eur)
Identification A (Relative density, 20°C): 1.320 to 1.332 (Ph.Eur)
Identification B (Refractive index, 20±0.5°C): 1.423 to 1.425 (Ph.Eur)
Identification C (By IR): IR Spectra of the sample should be concomitant with IR spectra of the corresponding standard. (USP/Ph.Eur)
Identification D (By chemical test): A violet color should produce. (Ph.Eur)
Identification E (By Chemical test): The precipitate should dissolve easily with the possible exception of a few large particles which dissolve slowly. (Ph.Eur)
Appearance of solution: Clear and colorless (Ph.Eur)
Relative density, 20°C: 1.320 to 1.332 (Ph.Eur)
Specific gravity,25°C: Between 1.318 and 1.322 (USP-NF)
Refractive index, 20°C ± 0.5°C: 1.423 to 1.425 (Ph.Eur)
Assay: NLT 99.0% (USP-NF)
Acidity: Not more than 0.15 mL of 0.1M sodium hydroxide is required to change the color of the indicator to blue. (Ph.Eur)
Limit of hydrogen chloride: 0.001% max. (USP-NF)
Free Chlorine (Cl): The lower layer does not show a violet tint. (USP-NF)
Ethanol, 2-methylbut-2-ene and volatile impurities: Ethanol: 2.0% v/v max. (Ph.Eur)
Ethanol, 2-methylbut-2-ene and volatile impurities: 2-methylbut-2-ene: 300 ppm v/v max. (Ph.Eur)
Impurity A (Carbon tetrachloride): 4 ppm v/v max. (Ph.Eur)
Impurity B (Chloroform): 50ppm v/v max. (Ph.Eur)
Sum of impurities other than ethanol and 2-methylbut-2-ene: 0.1% v/v max. (Ph.Eur)
Residue on evaporation: 20ppm max. (Ph.Eur)
Water: 0.02% m/m max. (USP/Ph.Eur)
Total aerobic microbial count: NMT 100 cfu/g (In-house)
Total combined yeast and molds count: NMT 10 cfu/g (In-house)
E.coli: Must be absent (In-house)
Bacterial endotoxins: NMT 0.1 EU/mg (In-house)
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